High-density lipoprotein particle number: a better measure to quantify high-density lipoprotein?
نویسندگان
چکیده
Limitations in our ability to predict cardiovascular risk have fueled efforts to identify novel risk markers and to refine the measurement of traditional risk factors, such as low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C). Standard assays to evaluate LDL-C and HDL-C quantify the cholesterol content within the respective lipoprotein fraction. However, both LDL and HDL particles vary in their content of cholesterol, and thus determining the concentration of lipoprotein particles themselves may be superior to counting cholesterol cargo in assessing cardiovascular risk. For example, there is 1 molecule of apolipoprotein B (apo B) per low-density liprotein-particle (LDL-P) and, thus, plasma concentrations of apo B more closely reflect LDL-P concentrations than levels of LDL-C. Some (1,2), but not all (3), prospective population studies indicate a stronger association between apo B and cardiovascular events than between LDL-C and cardiovascular events. Another approach to quantitation of lipoprotein particle concentrations utilizes nuclear magnetic resonance (NMR) spectroscopy. This method takes advantage of 2 important principles to permit rapid quantification of lipoprotein concentrations without requiring physical separation (4). First, each lipoprotein subclass emits a distinct signal when subjected to electromagnetic pulses in a magnetic field; second, the signal amplitudes generated are directly proportional to the concentration of the particles emitting the signal. Using a library of known lipids, sample signals can be deconvoluted to determine concentrations of individual lipoprotein subclasses. There is now abundant literature on
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ورودعنوان ژورنال:
- Journal of the American College of Cardiology
دوره 60 6 شماره
صفحات -
تاریخ انتشار 2012